N,N-bis(2-chloroethyl)carbamate tert-butyl ester can be used as an intermediate in pharmaceutical chemistry and organic synthesis. In organic synthesis transformations, the Boc group in the structure can be easily removed to obtain an active carboxyl group.

The synthetic method involves rapidly stirring a suspension of bis-(2-chloroethyl)amine hydrochloride (5 g, 0.028 mol) in dichloromethane (42 mL) with a 10% sodium hydroxide aqueous solution (28 mL) at an ice bath temperature. A solution of di-tert-butyl dicarbonate (6.11 g, 0.028 mol) in dichloromethane (28 mChemicalbook L) is then added. After stirring at room temperature for 18.5 hours, dichloromethane (30 mL) is slowly added to the reaction mixture. The two phases are then separated. The aqueous phase is further extracted with dichloromethane (30 mL). The combined organic layers are dried over anhydrous magnesium sulfate, filtered, and concentrated to obtain N,N-bis(2-chloroethyl)carbamate tert-butyl.