High quality 2-Hydroxypyridine supplier in China CAS NO.142-08-5
2-Hydroxypyridine
Pyridin-2(1H)-one;2-PYRIDONE;2(1h)-pyridinone;2-Pyridinol;Pyridin-2-one;2(1H)-PYRIDONE;2-PYRIDON;2-PYRIDOL;A-PYRIDONE;Pyridone-2
2-Hydroxypyridine is Colorless to yellow to brown, darken on storage with no loss of purity liquid. Soluble in water 450 g/L @ 20°C and ethanol, slightly soluble in benzene and ether.
| Chemical Name | 2-Hydroxypyridine |
| CAS | 142-08-5 |
| Molecular Formula | C5H5NO |
| Molecular Weight | C5H5NO |
| Density | 1.39 |
| Brand Name | Megawide |
Catalyst, used in the reaction of generating β-oxypropyl carbonate compounds from cyclic carbonate compounds and alcohol compounds, and in the ammonolysis reaction of polyglutamate esters.
Packaging Detail: 200 kg iron drum or as the request of customer.
- Molecular Formula: \(C_{5}H_{5}NO\)
- Molecular Weight: \(95.10 \text{ g/mol}\)
- Synonyms: 2-Pyridinol, 2-Pyridone, 2-Oxopyridine, Pyridin-2-ol, \(\alpha \)-Pyridone
- Appearance: White to off-white or light yellow solid
- Melting Point: Approx. \(104 \text{–} 107^\circ\text{C}\) (varies by source)
- Uses: Utilized as a catalyst in chemical reactions (e.g., in the formation of \(\beta \)-oxopropyl carbonates) and as a building block for pharmaceuticals and agrochemicals.
2-Hydroxypyridine usually appears as white or pale yellow particles or powders at room temperature and pressure. The molecular formula C5H5NO, CAS 142-08-5, contains a pyridine ring and a hydroxyl group in its molecular structure, which gives it a certain polarity and reactivity. Its boiling point is relatively high, generally between 280-281 ℃ (lit.) or 323.7 ± 15.0 ° C at 760 mmHg, indicating its high thermal stability. The acidity coefficient (pKa) is 0.75 (at 20 ℃), indicating that its hydroxyl group has a certain acidity and can undergo acid-base reactions under certain conditions. This compound has good water solubility, with a solubility of up to 450 g/L at 20 ° C. It is also easily soluble in ethanol, but has lower solubility in benzene and ether. This good water solubility makes it more widely used in the fields of medicine and chemical engineering. It has good reactivity and is widely used as a pharmaceutical synthesis intermediate and chemical raw material. In the field of medicine, it can be used to synthesize various bioactive compounds; In the field of chemical engineering, it can be used as a catalyst, ligand, or reaction intermediate.
| Chemical Formula | C5H5NO |
| Exact Mass | 95 |
| Molecular Weight | 95 |
| m/z | 95 (100.0%), 96 (5.4%) |
| Elemental Analysis | C, 63.15; H, 5.30; N, 14.73; O, 16.82 |
In the field of biochemistry, 2-hydroxypyridine (also known as 2-pyridinephenol or 2-pyridone) is an important organic compound with a wide range of applications.
As a raw material for synthesizing peptide segments
In biochemical research, peptide segments are the basic building blocks of proteins and are crucial for understanding the structure and function of proteins. Used as a raw material for synthesizing peptide segments, it can be transformed into peptide segments with specific sequences and functions through specific chemical reactions. This application not only helps to deepen the study of the relationship between protein structure and function, but also provides an important material basis for drug development and biotechnology applications.
Biochemical experimental research
It also plays an important role in biochemical experimental research. It can be used as an experimental reagent to participate in various biochemical reactions and experimental processes, helping scientists verify hypotheses, explore unknown fields, and promote scientific progress. For example, in enzymatic reaction research, 2-pyridone can be used as a substrate or inhibitor to explore the catalytic mechanism and substrate specificity of enzymes; In cell culture experiments, it can be used as a nutrient or signaling molecule to observe biological processes such as cell growth, differentiation, and apoptosis.
Biological pesticides and plant growth regulators
Although there are few reported cases of direct application as biopesticides or plant growth regulators, considering the biological activity and environmental friendliness of this substance and its derivatives, it may be developed into new types of biopesticides or plant growth regulators in the future. These compounds may promote plant growth, enhance stress resistance, and increase yield by regulating metabolic pathways and signaling networks within the plant body.
Basic Information and Chemical Properties
2-Hydroxypyridine (2-hydroxypyridine) is an important pyridine compound with the molecular formula C₅H₅NO, a molecular weight of 95.10, and a CAS number of 142-08-5 (some literature indicates it as 72762-00-6, which may be due to differences in purity or crystal form). It appears as white or light yellow granules, with a melting point range of 105-107°C, a boiling point of 280-281°C, a density of 1.39g /cm³, and good water solubility (up to 500g/L at 20°C), but slightly soluble in chloroform and methanol. This compound is weakly acidic, and its hydroxyl group (-OH) and the nitrogen atom (N) on the pyridine ring can participate in various chemical reactions, such as proton transfer and REDOX reactions.
Core Manufacturing Methods
Catalytic dechlorination method with 3,5, 6-trichloropyridinol
Process flow
Using 3,5, 6-trichloropyridinol as the raw material, organic solvents (such as ethanol, methanol) and ammonium formate were added. Under the action of palladium/carbon (Pd/C) catalyst, it was heated to 65-95°C and reflow for 5-8 hours. After the reaction is completed, the mixture is cooled and filtered by suction. The filter cake is washed with ethanol to recover the catalyst, and the mother liquor is concentrated and subjected to vacuum distillation to obtain 2-hydroxypyridine.
Key parameters
Raw material molar ratio: 3,5, 6-trichloropyridinol: ammonium formate = 1: (2-5)
Catalyst dosage: Add 1-2 grams of Pd/C per mole of raw material
Solvent selection: Ethanol is the best solvent (with a yield of up to 87.3%), followed by methanol (85.6%). Long-chain alcohols (such as n-propanol) have a reduced yield due to solubility issues (68.2%).
Advantages: The reaction conditions are mild (temperature below 100°C), the post-treatment is simple, and the yield is significantly higher than that of traditional methods (the yield of traditional methods is about 75%).
Hydrolysis method of 2-chloro-3-cyanopyridine
Process flow
Using 2-chloro-3-cyanopyridine as the raw material, it is hydrolyzed under alkaline or acidic conditions to produce 2-hydroxy-3-cyanopyridine (intermediate), and further de-cyanidation is carried out to obtain 2-hydroxy-pyridine.
Key parameters
Hydrolysis conditions: The pH value and temperature must be strictly controlled to avoid side reactions.
Yield: Approximately 97% (but multiple purification steps are required, resulting in higher costs).
Applicable scenarios: It is suitable for the preparation of high-purity 2-hydroxypyridine, but its industrial application is relatively rare.
Other synthetic routes
Isonicotinic acid oxidation method: Isonicotinic acid (4-pyridinic acid) is oxidized to 2-hydroxyisonicotinic acid, and then decarboxylated to obtain 2-hydroxypyridine, but the yield is relatively low (about 63%).
Pyridine ring modification method: Using pyridine as the raw material, the -OH group is introduced through hydroxylation reaction, but the steps are cumbersome and the industrial value is limited.
Direction of Manufacturing Process Optimization
Catalyst improvement
Traditional Pd/C catalysts are costly and prone to deactivation. Research on new non-precious metal catalysts (such as nickel-based catalysts) or supported catalysts (such as Pd/Al₂O₃) can reduce costs and enhance stability.
Solvent recovery and recycling
Organic solvents (such as ethanol) account for a relatively high proportion of production costs. The development of solvent recovery technologies (such as distillation and adsorption) can significantly reduce raw material consumption.
Continuous production
Traditional batch reactions have problems of low efficiency and high energy consumption. Designing a continuous flow reactor to achieve continuous addition of raw materials and real-time separation of products can enhance production efficiency.
Green synthetic route
Explore green synthesis methods such as photocatalysis and electrochemical catalysis to reduce the use of toxic reagents (such as ammonium formate) and lower environmental pollution.
Application Fields and Market Demands
2-hydroxypyridine, as an intermediate in the fields of pharmaceuticals, pesticides and chemicals, has seen a continuous increase in market demand.
In the medical field: It is used for the synthesis of anti-tuberculosis drugs (such as isoniazid), anti-tumor drugs and neuroprotective agents.
In the field of pesticides: As an intermediate for herbicides and fungicides.
In the field of chemical engineering: It is used for the preparation of dyes, rubber additives and photosensitive materials.
According to data from market research institutions, the global market size of 2-hydroxypyridine is expected to grow at a compound annual growth rate of 5% to 7%, and the market size is expected to exceed 100 million US dollars by 2025.
| MIT-IVY INDUSTRYCO.,LTD local :69 park Xuzhou City,Jiangsu Province,China Athena: TEL/WHATSAPP:0086-13805212761 EMAIL:ceo@mit-ivy.com http://www.mit-ivy.com Mit-Ivy factory is a well-known N -Aniline series fine chemicals manufacturer in China. Mainly involved,N Aniline series products，resin series products. |
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