N,N-dihydroxyethyl-p-methylaniline is in the form of a colorless to pale yellow solid or a pale yellow to yellowish brown liquid. Specifically, it can also appear as a white to slightly yellow crystalline powder, or pale yellow block crystals. This substance is soluble in a variety of organic solvents, but is difficult to dissolve in water.

N,N-dihydroxyethyl-p-methylaniline has a wide range of uses, mainly including the following aspects:

‌1. Dye intermediates:
Because its structure contains phenolic and ethyl groups, it can give dyes good solubility and stability, so it has become a key intermediate for the synthesis of a variety of chromatographic dyes and is widely used in staining analysis, staining microscopy and other fields.

‌2. Pharmaceutical intermediates:
In drug research and development, N,N-dihydroxyethyl-p-methylaniline is an important intermediate for the synthesis of certain anti-disease drugs, such as butacyclovir (an antiviral drug) and certain anti-cancer drugs, providing important raw materials for drug research and development. At the same time, it can also be used as a stabilizer and antioxidant for drugs to improve the stability and efficacy of drugs.

‌3. Adhesive industry‌:
As a tackifier, it can improve the adhesion and viscosity of adhesives, thereby enhancing the performance of adhesives. It is widely used in wood gluing, textile gluing, paper gluing and other processes.

‌4. Cosmetics industry‌:
In cosmetics, N,N-dihydroxyethyl-p-methylaniline can be used as an antioxidant and stabilizer to effectively inhibit the oxidation of oils in cosmetics, extend the shelf life of cosmetics, and adjust the pH of cosmetics to make them more suitable for the pH value of human skin and reduce skin irritation.

In addition, N,N-dihydroxyethyl-p-methylaniline can also be used to synthesize various resins, coatings, inks, etc. to improve the performance of these products, such as increasing hardness, wear resistance, corrosion resistance, etc., and can be used as a catalyst and initiator to promote chemical reactions.

2,2′-(P-TOLYLIMINO)DIETHANOL Chemical Properties
Melting point 49-53 °C (lit.)
Boiling point 338-340 °C (lit.)
density 1.0654 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.5330 (estimate)
Fp >230 °F
storage temp. Inert atmosphere,Room Temperature
solubility soluble in Methanol
pka 14.33±0.10(Predicted)
form powder to lump to clear liquid
color White or Colorles to Yellow to Orange
Water Solubility 19.8g/L at 20℃
BRN 2099156
InChIKey JUVSRZCUMWZBFK-UHFFFAOYSA-N
LogP 2 at 35℃
CAS DataBase Reference 3077-12-1(CAS DataBase Reference)
EPA Substance Registry System Ethanol, 2,2′-[(4-methylphenyl)imino]bis- (3077-12-1)

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