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3-chlorobenzoic acid is an important chemical raw material and intermediate widely used in various organic reactions. ‌

3-chlorobenzoic acid has important applications in the pharmaceutical field. It is a key synthetic material for drugs such as loratadine and bupropion. Loratadine is a second-generation antihistamine drug commonly used to treat allergic symptoms such as allergic rhinitis, acute or chronic urticaria, allergic conjunctivitis, hay fever, and other allergic skin diseases. Amphetamine belongs to the category of amino ketone antidepressants and is suitable for treating chronic depression as well as depression patients who are not significantly effective or intolerant to other antidepressants.

In addition, 3-chlorobenzoic acid is also used in the synthesis of dyes and insecticides. As a fundamental chemical building block, it is commonly used in the synthesis of complex organic structures. Through reactions such as oxidation, reduction, and substitution, various organic compounds can be synthesized, such as drugs, dyes, insecticides, etc

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3-Chlorobenzoic acid Chemical Properties
Melting point 153-157 °C (lit.)
Boiling point 274-276°C
density 1.496
refractive index 1.5812 (estimate)
Fp 150 °C
storage temp. Store below +30°C.
solubility 0.45g/l
form Crystalline Powder
pka 3.82(at 25℃)
color White to beige
Water Solubility <0.1 g/100 mL at 19.5 ºC
Merck 14,2123
BRN 907218
Stability: Skin, eye and respiratory irritant.
CAS DataBase Reference 535-80-8(CAS DataBase Reference)
NIST Chemistry Reference Benzoic acid, 3-chloro-(535-80-8)
EPA Substance Registry System m-Chlorobenzoic acid (535-80-8)

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Post time: Oct-08-2024