N-methylacetamide has a wide range of uses, mainly reflected in the following aspects:

‌Organic solvent‌: N-methylacetamide is a colorless and transparent liquid with good water solubility. It can be used as a general polar solvent to dissolve many compounds that are not easily soluble in conventional organic solvents.

‌Basic raw materials in the pharmaceutical industry‌: In the pharmaceutical production industry, N-methylacetamide is a commonly used basic raw material and can be used to synthesize widely used drugs such as cephalosporin antibiotics.

Organic synthesis intermediates‌: N-methylacetamide is used as an intermediate in organic synthesis of pesticides, medicines, etc., and participates in a variety of organic reactions, such as oxidation, reduction, hydroxylation, alkylation, and arylation.

‌Chemical reaction catalyst and deacidifying agent‌: This compound has a catalytic effect on certain chemical reactions and is also a deacidifying agent in non-polar solvents.

In summary, N-methylacetamide has wide application value in chemical industry, pharmaceutical and other fields‌

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N-Methylacetamide Chemical Properties
Melting point 26-28 °C (lit.)
Boiling point 204-206 °C (lit.)
density 0.957 g/mL at 25 °C (lit.)
vapor pressure 12-3680Pa at 15-113℃
refractive index n20/D 1.433(lit.)
Fp 227 °F
storage temp. Inert atmosphere,Room Temperature
solubility miscible with ethanol, ether, acetone, water, chloroform, benzene
pka 16.61±0.46(Predicted)
form Solid
color Colourless
PH 7 (H2O)
explosive limit 3.2-18.1%(V)
Water Solubility soluble
BRN 1071255
Dielectric constant 178.90000000000001
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey OHLUUHNLEMFGTQ-UHFFFAOYSA-N
LogP -1.05–0.7 at 25℃
CAS DataBase Reference 79-16-3(CAS DataBase Reference)
NIST Chemistry Reference Acetamide, N-methyl-(79-16-3)
EPA Substance Registry System N-Methylacetamide (79-16-3)

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