N,N-Dimethylformamide dimethyl acetal (abbreviated as DMF-DMA) has a wide range of applications. It serves as a crucial intermediate in the synthesis of heterocyclic compounds and functions effectively as a methylating agent and a dehydrating agent. Notably, as a pharmaceutical synthesis intermediate, it is used in the production of drugs such as 1,2,3-triazoles, quinolones, ofloxacin, and milrinone.

N,N-Dimethylformamide dimethyl acetal

CAS No. 4637-24-5;

Molecular Formula C5H13NO2;

Molecular Weight 119.16;

EINECS No. 225-063-3.

Melting point -85°C;

Boiling point 102-103°C/720 mmHg (lit.);

Density 0.897 g/mL at 25°C (lit.);

Vapor pressure 34.5 hPa at 20°C;

Refractive index n20/D 1.396 (lit.);

Flash point 45°F;

Storage conditions: Store below +30°C;

Solubility: Miscible with most organic solvents;

Form: Solid;

Acidity constant (pKa): 5.00 ± 0.50 (Predicted);

Color: White to off-white.

Applications: Intermediate for organic and pharmaceutical synthesis; precursor for formamidine synthesis. Used in the preparation of 1,2,3-triones and indoles, and as a condensing agent for quinolone drugs. It can be used to synthesize drugs such as ofloxacin, milrinone, and allopurinol. It also serves as an intermediate for the drug zaleplon.

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